Journal of Medicinal Chemistry
Volume 39, Issue 6 (March 15, 1996)
Copyright © 1996 American Chemical Society

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1193-1195

Synthesis and Pharmacologic Evaluation of 2-endo-Amino-3-exo- isopropylbicyclo[2.2.1]heptane: A Potent Imidazoline1 Receptor Specific Agent Stephen A. Munk, Ronald K. Lai, James E. Burke, Premilla N. Arasasingham, Alexander B. Kharlamb, Cynthia A. Manlapaz, Edwin U. Padillo, Mercy K. Wijono, Dain W. Hasson, Larry A. Wheeler, and Michael E. Garst [Full Article - PDF]

1196-1200

Endogenous Natriuretic Factors. 5. Synthesis and Biological Activity of a Natriuretic Metabolite of Diltiazem and Its Derivatives Darko Kantoci, E. David Murray, Jr., David D. Quiggle, and William J. Wechter [Full Article - PDF]

1201-1209

Synthesis and Pharmacology of Potential Cocaine Antagonists. 2. Structure-Activity Relationship Studies of Aromatic Ring-Substituted Methylphenidate Analogs Howard M. Deutsch, Qing Shi, Ewa Gruszecka-Kowalik, and Margaret M. Schweri [Full Article - PDF]

1210-1219

Optimal Recognition of Neutral Endopeptidase and Angiotensin-Converting Enzyme Active Sites by Mercaptoacyldipeptides as a Means To Design Potent Dual Inhibitors Pascale Coric, Serge Turcaud, Hervé Meudal, Bernard Pierre Roques, and Marie-Claude Fournie-Zaluski [Full Article - PDF]

1220-1226

[125I]Iodoproxyfan and Related Compounds: A Reversible Radioligand and Novel Classes of Antagonists with High Affinity and Selectivity for the Histamine H3 Receptor Holger Stark, Katja Purand, Annette Hüls, Xavier Ligneau, Monique Garbarg, Jean-Charles Schwartz, and Walter Schunack [Full Article - PDF]

1227-1235

Molecular Modeling of Azole Antifungal Agents Active against Candida albicans. 1. A Comparative Molecular Field Analysis Study Andrea Tafi, Jane Anastassopoulou, Theophile Theophanides, Maurizio Botta, Federico Corelli, Silvio Massa, Marino Artico, Roberta Costi, Roberto Di Santo, and Rino Ragno [Full Article - PDF]

1236-1242

Nuclear Magnetic Resonance and Molecular Modeling Study on Mycophenolic Acid: Implications for Binding to Inosine Monophosphate Dehydrogenase Gergely M. Makara, György M. Keserû, Mária Kajtár-Peredy, and Wayne K. Anderson [Full Article - PDF]

1243-1252

Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 17. Structure-Activity Relationships of Several Series of Compounds Derived from N-Chlorosulfonyl Isocyanate Joseph A. Picard, Patrick M. O'Brien, Drago R. Sliskovic, Maureen K. Anderson, Richard F. Bousley, Katherine L. Hamelehle, Brian R. Krause, and Richard L. Stanfield [Full Article - PDF]

1253-1261

Cationic [99mTcIII(DIARS)2(SR)2]+ Complexes as Potential Myocardial Perfusion Imaging Agents (DIARS = o-phenylenebis(dimethylarsine); SR- = thiolate) Francesco Tisato, Theodosia Maina, Li-Ren Shao, Mary Jane Heeg, and Edward Deutsch [Full Article - PDF]

1262-1270

Potent Inhibitors of Acyl-CoA:Cholesterol Acyltransferase. 2. Structure-Activity Relationships of Novel N-(2,2-Dimethyl-2,3-dihydrobenzofuran-7-yl)amides Ken-ichiro Kataoka, Tatsuki Shiota, Takumi Takeyasu, Toru Minoshima, Kenzo Watanabe, Hiroko Tanaka, Tsutomu Mochizuki, Keiko Taneda, Mikio Ota, Hirofumi Tanabe, and Hisao Yamaguchi [Full Article - PDF]

1271-1280

Lipophilic Antifolates as Agents against Opportunistic Infections. 1. Agents Superior to Trimetrexate and Piritrexim against Toxoplasma gondii and Pneumocystis carinii in in Vitro Evaluations James R. Piper, Cheryl A. Johnson, Charles A. Krauth, Ronald L. Carter, Carla A. Hosmer, Sherry F. Queener, Susan E. Borotz, and Elmer R. Pfefferkorn [Full Article - PDF]

1281-1292

An NMR, CD, Molecular Dynamics, and Fluorometric Study of the Conformation of the Bradykinin Antagonist B-9340 in Water and in Aqueous Micellar Solutions Jan Sejbal, John R. Cann, John M. Stewart, Lajos Gera, and George Kotovych [Full Article - PDF]

1293-1302

Angular Furoquinolinones, Psoralen Analogs: Novel Antiproliferative Agents for Skin Diseases. Synthesis, Biological Activity, Mechanism of Action, and Computer-Aided Studies Paolo Rodighiero, Adriano Guiotto, Adriana Chilin, Franco Bordin, Francarosa Baccichetti, Francesco Carlassare, Daniela Vedaldi, Sergio Caffieri, A. Pozzan, and Francesco Dall'Acqua [Full Article - PDF]

1303-1313

Synthesis, Chromatographic Resolution, and Anti-Human Immunodeficiency Virus Activity of (±)-Calanolide A and Its Enantiomers Michael T. Flavin, John D. Rizzo, Albert Khilevich, Alla Kucherenko, Abram K. Sheinkman, Vilayphone Vilaychack, Lin Lin, Wei Chen, Eugenia Mata Greenwood, Thitima Pengsuparp, John M. Pezzuto, Stephen H. Hughes, Thomas M. Flavin, Michael Cibulski, William A. Boulanger, Robert L. Shone, and Ze-Qi Xu [Full Article - PDF]

1314-1320

Synthesis and Biological Evaluation of N-Acetylneuraminic Acid-Based Rotavirus Inhibitors Milton J. Kiefel, Birgit Beisner, Simon Bennett, Ian D. Holmes, and Mark von Itzstein [Full Article - PDF]

1321-1330

Synthesis and Antiviral Activity of Pyranosylphosphonic Acid Nucleotide Analogues Petr Alexander, V. V. Krishnamurthy, and Ernest J. Prisbe [Full Article - PDF]

1331-1338

Novel -Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonists: Synthesis and Structure-Activity Relationships of 6-(1H-Imidazol-1-yl)- 7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and Related Compounds Junya Ohmori, Hirokazu Kubota, Masao Shimizu-Sasamata, Masamichi Okada, and Shuichi Sakamoto [Full Article - PDF]

1339-1343

Studies on Selectin Blocker. 1. Structure-Activity Relationships of Sialyl Lewis X Analogs Hiroshi Ohmoto, Kenji Nakamura, Tomomi Inoue, Noriko Kondo, Yoshimasa Inoue, Kohichiro Yoshino, and Hirosato Kondo , Hideharu Ishida, Makoto Kiso, and Akira Hasegawa [Full Article - PDF]

1344-1344

The Adventure Playground of Mechanisms and Novel Reactions By Rolf Huisgen, in Profiles, Pathways, and Dreams. Edited by Jeffrey I. Seeman. American Chemical Society, Washington, D.C. 1994. XXIV + 279 pp. 15 × 23 cm. ISBN 0-8412-1832-3. $24.95. Heinrich Zollinger [Full Article - PDF]